Evaluation of seven tumour markers in pleural fluid for the diagnosis of malignant effusions
作者： M Miédougé , P Rouzaud , G Salama , M-C Pujazon , C Vincent
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摘要: Carcinoembryonic antigen (CEA), carbohydrate antigens 15-3, 19-9 and 72-4 (CA CA 72-4), cytokeratin 19 fragments (CYFRA 21-1), neuron-specific enolase (NSE) squamous cell carcinoma (SCC) were evaluated in pleural fluid for the diagnosis of malignant effusions. With a specificity 99%, determined series 121 benign effusions, best individual diagnostic sensitivities whole 215 effusions or subgroup adenocarcinomas observed with CEA, 15-3 72-4. As expected, high sensitivity was obtained SCC carcinomas NSE small-cell lung carcinomas. CYFRA and/or frequently increased mesotheliomas. Discriminant analysis showed that optimal combination non-lymphomatous CEA + NSE: 94.4% an overall 95%. In negative cytology, 83.9% diagnosed using this association. The association able to discriminate from cancers. Regarding their complementarity, 21-1, appear be very useful improve
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