Interactions among the variants of insulin-related genes and nutrients increase the risk of type 2 diabetes.
作者： Kyung-Won Hong , Sung Hoon Kim , Xin Zhang , Sunmin Park
DOI: 10.1016/J.NUTRES.2017.12.012
关键词:
摘要: Abstract Asians easily develops type 2 diabetes (T2DM) since they have insufficient glucose-stimulated insulin secretion (GSIS) in resistant states. Since this may be associated with genetic background, the hypothesis of study was that inter-genetic and gene-nutrient interactions explain low secretory capacity Asians. Accordingly, we identified best gene-gene using generalized multifactor dimensionality reduction (GMDR) a large Korean cohort (n=8,842). Initially, used 105 variants GSIS to identify interaction model GMDR method. The included six SNPs, FNBP1L-rs4847428, FNBP1L-rs23766, GLIS3-rs2027393, GLIS3-rs3892354, GLIS3-rs486163 DLC1-rs17093957. For each individual, obtained risk scores based on (GRSBM) predict levels. GRSBM were divided into low, medium high groups, association between T2DM measured logistic regression. We analyzed nutrition intakes. adjusted odds ratios for increased by 1.701 fold high-score group compared low-score group. HOMA-B, an index capacity, but not resistance much lower than greater subjects energy intakes Ca intake, those intake intake. susceptible incidence due especially In conclusion, accepted. These findings suggested individuals 6 genes should avoid diets calcium (
sci-hub.se 参考文章(42)
Örjan Carlborg, Chris S. Haley, Epistasis: too often neglected in complex trait studies? Nature Reviews Genetics. ,vol. 5, pp. 618- 625 ,(2004) , 10.1038/NRG1407
Kommoju Uma Jyothi, Battini Mohan Reddy, Gene–gene and gene–environment interactions in the etiology of type 2 diabetes mellitus in the population of Hyderabad, India Meta Gene. ,vol. 5, pp. 9- 20 ,(2015) , 10.1016/J.MGENE.2015.05.001
Sunmin Park, Jaeouk Ahn, Byung-Kook Lee, Self-rated Subjective Health Status Is Strongly Associated with Sociodemographic Factors, Lifestyle, Nutrient Intakes, and Biochemical Indices, but Not Smoking Status: KNHANES 2007-2012. Journal of Korean Medical Science. ,vol. 30, pp. 1279- 1287 ,(2015) , 10.3346/JKMS.2015.30.9.1279
Z. Wang, D. C. Thurmond, Mechanisms of biphasic insulin-granule exocytosis – roles of the cytoskeleton, small GTPases and SNARE proteins Journal of Cell Science. ,vol. 122, pp. 893- 903 ,(2009) , 10.1242/JCS.034355
Xiang-Yang Lou, Guo-Bo Chen, Lei Yan, Jennie Z. Ma, Jun Zhu, Robert C. Elston, Ming D. Li, A Generalized Combinatorial Approach for Detecting Gene-by-Gene and Gene-by-Environment Interactions with Application to Nicotine Dependence American Journal of Human Genetics. ,vol. 80, pp. 1125- 1137 ,(2007) , 10.1086/518312
Ingeborg Hers, Matthew Wherlock, Yoshimi Homma, Hitoshi Yagisawa, Jeremy M. Tavaré, Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells. Journal of Biological Chemistry. ,vol. 281, pp. 4762- 4770 ,(2006) , 10.1074/JBC.M511008200
Y Ahn, E Kwon, J E Shim, M K Park, Y Joo, K Kimm, C Park, D H Kim, Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study. European Journal of Clinical Nutrition. ,vol. 61, pp. 1435- 1441 ,(2007) , 10.1038/SJ.EJCN.1602657
N. Rabbee, T. P. Speed, A genotype calling algorithm for affymetrix SNP arrays Bioinformatics. ,vol. 22, pp. 7- 12 ,(2006) , 10.1093/BIOINFORMATICS/BTI741
Hai-Ming Xu, Xi-Wei Sun, Ting Qi, Wan-Yu Lin, Nianjun Liu, Xiang-Yang Lou, Multivariate Dimensionality Reduction Approaches to Identify Gene-Gene and Gene-Environment Interactions Underlying Multiple Complex Traits PLoS ONE. ,vol. 9, pp. e108103- ,(2014) , 10.1371/JOURNAL.PONE.0108103
Ele Ferrannini, Andrea Mari, β-Cell function in type 2 diabetes Metabolism. ,vol. 63, pp. 1217- 1227 ,(2014) , 10.1016/J.METABOL.2014.05.012