Gene–gene and gene–environment interactions in the etiology of type 2 diabetes mellitus in the population of Hyderabad, India

摘要: Fifteen SNPs from nine different genes were genotyped on 1379 individuals, 758 T2DM patients and 621 controls, the city of Hyderabad, India, using Sequenom Massarray platform. These data analyzed to examine role gene–gene gene–environment interactions in manifestation T2DM. The multivariate analysis suggests that TCF7L2, CDKAL1, IGF2BP2, HHEX PPARG are significantly associated with T2DM, albeit only first two above 5 univariate analysis. Significant also observed reference CAPN10 CDKAL1 genes, highlighting their importance pathophysiology In for cumulative effect risk alleles, SLC30A8 steps as significant contributor disease by its presence all combinations alleles. A striking difference between allele categories, 1–4 5–6, was evident showing protective susceptible roles, respectively, while latter characterized TCF7L2 variants. Overall, these showed strong association either individually or interaction other genes. However, we need further studies among heterogeneous Indian populations obtain unequivocal conclusions applicable population a whole.