Investigation of Phosphoproteome in RAGE signaling

摘要: The receptor for advanced glycation end products (RAGE) is one of the most important proteins implicated in diabetes, cardiovascular diseases, neurodegenerative and cancer. It a pattern recognition by virtue its ability to interact with multiple ligands, RAGE activates several signal transduction pathways through involvement various kinases that phosphorylate their respective substrates. Only few substrates have been known be phosphorylated response activation (e.g., nuclear factor kappa B); however, it possible these can depending upon expression localization, leading altered cellular responses different cell types conditions. One such example is, glycogen synthase kinase 3 beta which synthase, acts downstream RAGE, hyperphosphorylates microtubule-associated protein tau causing neuronal damage. Thus, understand role RAGE-activated Therefore, we reviewed here details ligands phosphoproteome. Furthermore, discuss analysis data mined from PhosphoSitePlus (http://www.phosphosite.org) database, some involved cancer, diseases. In summary, this review provides information on phosphoproteome, will helpful understanding progression