Malaria Derived Glycosylphosphatidylinositol Anchor Enhances Anti-Pfs25 Functional Antibodies That Block Malaria Transmission.
作者： Neeraj Kapoor , Ivana Vanjak , James Rozzelle , Aym Berges , Wei Chan
DOI: 10.1021/ACS.BIOCHEM.7B01099
关键词:
摘要: Malaria, one of the most common vector borne human diseases, is a major world health issue. In 2015 alone, more than 200 million people were infected with malaria, out which, 429 000 died. Even though artemisinin-based combination therapies (ACT) are highly effective at treating malaria infections, novel efforts toward development vaccines to prevent transmission still needed. Pfs25, postfertilization stage parasite surface antigen, leading transmission-blocking vaccine (TBV) candidate. It postulated that Pfs25 anchors cell membrane using glycosylphosphatidylinositol (GPI) linker, which itself possesses pro-inflammatory properties. this study, Escherichia coli derived extract (XtractCF+TM) was used in free protein synthesis [CFPS] successfully express >200 mg/L recombinant C-terminal non-natural amino acid (nnAA), namely, p-azidomethyl phenylalanine (pAMF), reactive azide group. Thereafter, unique conjugate (CV), P...
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