Bleeding time in rats: a comparison of different experimental conditions.

摘要: The tail bleeding time (BT) in rats definitely varies according to the method applied. Of various variables that may influence BT, we have evaluated position (horizontal or vertical) of tail, environment (air saline), temperature (4 degrees, 23 degrees 37 C) and type anaesthesia. Transection tip cannot be used screen drugs active on platelet function since it is sensitive coagulation defects. Template BT contrast not modified by heparin defects number ("storage pool disease", dipyridamole-like drugs, exogenous prostacyclin). In test fails detect aspirin-induced dysfunction. evidence reported indicates thromboxane A2-prostacyclin balance a factor regulating BT. Aspirin treatment however precipitating when associated with other abnormalities function. valid screening for disorders antiplatelet drugs.