Isthmin 1 is a secreted protein expressed in skin, mucosal tissues, and NK, NKT, and th17 cells.

摘要: Using a comprehensive microarray database of human gene expression, we identified that in mammals, secreted protein known as isthmin 1 (ISM1) is expressed skin, mucosal tissues, and selected lymphocyte populations. ISM1 was originally Xenopus brain during development, it encodes predicted ∼50-kDa containing signal peptide, thrombospondin domain, an adhesion-associated domain. We confirmed the pattern expression both mouse tissues. by DX5+ lung lymphocytes include NK NKT-like cells, also some CD4+ T cells upon activation but its increases significantly when were polarized to Th17 lineage vitro. The presence IFN-γ cell polarization inhibits expression. Given has been reported have anti-angiogenic properties, these observations suggest mediator effector functions may participate innate acq...