Perfusion Imaging with SPECT in the Era of Pathophysiology-Based Biomarkers for Alzheimer's Disease
作者： Markus Weih , Ümüt Degirmenci , Sebastian Kreil , Piotr Lewczuk , Daniela Schmidt
DOI: 10.4061/2010/109618
关键词:
摘要: SPECT allows registration of regional cerebral blood flow (rCBF) which is altered in a characteristic temporoparietal pattern Alzheimer's Dementia. Numerous studies have shown the diagnostic value reduced and metabolic changes using perfusion FDG-PEPT AD diagnosis as well differential against frontotemporal dementia, dementia with Lewy bodies vascular disease. Recently more pathophysiology-based biomarkers CSF Amyloid-PET tracers been developed that probably higher accuracy than indirect rCBF seen SPECT. In paper review, we describe recent advances improvements technique.
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