Impact of Cyclodextrins on Postprandial Glycemia: Evaluation in Experimental Animal Model Using the Real-Time Continuous Glucose Monitoring System
作者： Mauricio Fumio Sybuia , Márcio Guilhermetti , Camila Sampaio Mangolim , Roberto Barbosa Bazotte , Graciette Matioli
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摘要: Abstract The impact of cyclodextrins (CDs) on postprandial glycemic response employing the real-time continuous glucose monitoring system (RT-CGMS) was investigated. For this purpose, α-CD, β-CD, γ-CD, HP-β-CD, curdlan, and dextrin at doses 10 100 mg/kg were orally administered in rats. RT-CGMS efficient to evaluate CDs glycemia. results showed that dextrin, curdlan did not reduce after administration starch. In contrast, HP-β-CD (100 mg/kg) attenuated rise Moreover, γ-CD blunts excursion 100 mg/kg. Therefore, could attenuate glycemia promoted by oral Considering treatment hyperglycemia is necessary prevent type 2 diabetes, study opens perspective better control addition food.
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