Neuropeptides in respiratory medicine

摘要: Part 1 Innervation of the Airways: Neuropeptides and Classic - Neural Structures in Human Airways Functional Autonomic The Cholinergic Adrenergic Systems Lower Investigated by Modem Microscopy Control Upper Respiratory Tract Peptide Biosynthesis Secretion Some Recent Developments Unresolved Issues Vasoactive Intestinal Polypeptide Neuropeptide Y Sensory Nerves Tachykinins Pulmonary Endocrine Cells In Vivo Vitro Molecular Characterization Receptors Tachykinin Receptor Antagonists Peptidases General Principles Metabolism Biology Angiotensin Converting Enzyme, Neutral Endopeptidase 24.11, Carboxypeptidase M Localization Actions M. 2 Physiological Functions Concept Neurogenic Inflammation Modulation Peptidase Airway Vascular Beds Basophil Mast Cell Activation Inositol Triphosphate Smooth Muscle Function Macromolecule ATP as Neurally Released Modulator Ion Transport Effects on Neurotransmission Airways. 3 Pathophysiological Contribution to Disease: Asthma Inflammatory Mechanisms Cystic Fibrosis Lung Disease Allergic Rhinitis Small Carcinoma Neuroregulation Immunity Roles Substance P an Animal Model Hyperpnoea-induced Bronchoconstriction Nitric Oxide Guanylyl Cyclases Correlation with Bronchoalveolar Lavage Morphology lnflammation Plasma Protein Movement Across Mucosa Epithelium.