Active DNA demethylation by Gadd45 and DNA repair
作者： Christof Niehrs , Andrea Schäfer
DOI: 10.1016/J.TCB.2012.01.002
关键词:
摘要: How DNA methylation patterns are established, maintained and remodeled is incompletely understood, however, it has become clear that reversible dynamic as a result of enzymatic demethylation. Several different mechanisms may account for demethylation have recently been put forward all seem to involve repair. Here, we review mediated by multifunctional growth arrest damage 45 (Gadd45) protein family members which mediate during cell differentiation stress response. Gadd45 recruits nucleotide and/or base excision repair factors gene-specific loci acts an adapter between chromatin, thereby creating nexus epigenetics
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sci-hub.se 参考文章(92)
R A Gjerset, D W Martin, Presence of a DNA demethylating activity in the nucleus of murine erythroleukemic cells. Journal of Biological Chemistry. ,vol. 257, pp. 8581- 8583 ,(1982) , 10.1016/S0021-9258(18)34161-9
J.Christopher Fromme, Gregory L. Verdine, Base Excision Repair Advances in Protein Chemistry. ,vol. 69, pp. 1- 41 ,(2004) , 10.1016/S0065-3233(04)69001-2
James E. Cleaver, Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nature Reviews Cancer. ,vol. 5, pp. 564- 573 ,(2005) , 10.1038/NRC1652
M. Christine Hollander, M. Saeed Sheikh, Dmitry V. Bulavin, Karen Lundgren, Laura Augeri-Henmueller, Ronald Shehee, Thomas A. Molinaro, Kate E. Kim, Eva Tolosa, Jonathan D. Ashwell, Michael P. Rosenberg, Qimin Zhan, Pedro M. Fernández-Salguero, William F. Morgan, Chu-Xia Deng, Albert J. Fornace, Genomic instability in Gadd45a- deficient mice Nature Genetics. ,vol. 23, pp. 176- 184 ,(1999) , 10.1038/13802
France Carrier, Philippe T. Georgel, Philippe Pourquier, Mellissa Blake, H. Udo Kontny, Michael J. Antinore, Marzia Gariboldi, Timothy G. Myers, John N. Weinstein, Yves Pommier, Albert J. Fornace, Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin Molecular and Cellular Biology. ,vol. 19, pp. 1673- 1685 ,(1999) , 10.1128/MCB.19.3.1673
Christian Popp, Wendy Dean, Suhua Feng, Shawn J. Cokus, Simon Andrews, Matteo Pellegrini, Steven E. Jacobsen, Wolf Reik, Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by Aid deficiency Nature. ,vol. 463, pp. 1101- 1105 ,(2010) , 10.1038/NATURE08829
Qimin Zhan, Michael J Antinore, Xin Wei Wang, France Carrier, Martin L Smith, Curtis C Harris, Albert J Fornace, Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene. ,vol. 18, pp. 2892- 2900 ,(1999) , 10.1038/SJ.ONC.1202667
Mark Wossidlo, Toshinobu Nakamura, Konstantin Lepikhov, C. Joana Marques, Valeri Zakhartchenko, Michele Boiani, Julia Arand, Toru Nakano, Wolf Reik, Jörn Walter, 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming Nature Communications. ,vol. 2, pp. 241- 241 ,(2011) , 10.1038/NCOMMS1240
Sally K. Mak, Dietmar Kültz, Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress. Journal of Biological Chemistry. ,vol. 279, pp. 39075- 39084 ,(2004) , 10.1074/JBC.M406643200
Andrea Schäfer, Lars Schomacher, Guillermo Barreto, Gabi Döderlein, Christof Niehrs, Gemcitabine Functions Epigenetically by Inhibiting Repair Mediated DNA Demethylation PLoS ONE. ,vol. 5, pp. e14060- ,(2010) , 10.1371/JOURNAL.PONE.0014060