The prevalence of GB virus C/hepatitis G virus RNA among healthy and HCV-infected Catalan children.

作者: Gemma Claret , Antoni Noguera , Araceli González-Cuevas , Juan José García-García , Clàudia Fortuny

DOI: 10.1007/S00431-007-0624-7

关键词:

摘要: GB virus C (GBV-C) is a blood-borne flavivirus. The prevalence of GBV-C viremia among healthy adults 0.5% to 4% and, date, no disease has been definitely associated with infection. We conducted cross-sectional study evaluate in group 327 children normal alanine amino transferase (ALT) levels (Group A) and elevated ALT B) unknown origin, 38 pediatric patients mother-to-child-transmitted hepatitis (HCV) infection C). No statistically significant differences were observed between prevalences Groups A B (2.2% vs 6.7%, p = 0.06). None the or who tested positive for RNA showed any clinical symptoms. Group was lower than 13.2%, 0.007); HCV characteristics those co-infected not. In conclusion, while more frequent HCV-infected patients, it neither liver nor influence on HCV-related chronic hepatitis.

参考文章(23)
Chia-Yen Dai, Shinn-Cherng Chen, Zu-Yau Lin, Wan-Long Chuang, Ming-Yuh Hsieh, Jeng-Fu Yang, Ming-Lung Yu, Jung-Fa Tsai, Wen-Yu Chang, Liang-Yen Wang, Wen-Yi Lin, Prevalence and Clinical Significance of HGV/GBV-C Infection in Patients with Chronic Hepatitis B or C Japanese Journal of Infectious Diseases. ,vol. 59, pp. 25- 30 ,(2006)
Minji Jo, Tae-Hyoung Kim, Dai-Wu Seol, James E. Esplen, Kenneth Dorko, Timothy R. Billiar, Stephen C. Strom, Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand Nature Medicine. ,vol. 6, pp. 564- 567 ,(2000) , 10.1038/75045
Susan Schuval, Jane C Lindsey, Jack T Stapleton, Russell B Van Dyke, Paul Palumbo, Lynne M Mofenson, James M Oleske, Joseph Cervia, Andrea Kovacs, Wayne N Dankner, Elizabeth Smith, Barbara Nowak, Gregory Ciupak, Nancy Webb, Michelle Eagle, Dorothy Smith, Roslyn Hennessey, Melissa Goodman-Kerkau, Donna Klinzman, Georg Hess, Dietmar Zdunek, Myron J Levin, None, GB virus C infection in children with perinatal human immunodeficiency virus infection Pediatric Infectious Disease Journal. ,vol. 24, pp. 417- 422 ,(2005) , 10.1097/01.INF.0000160943.17750.94
WK Roth, D Waschk, S Marx, S Tschauder, S Zeuzem, H Bialleck, H Weber, E Seifried, Prevalence of hepatitis G virus and its strain variant, the GB agent, in blood donations and their transmission to recipients. Transfusion. ,vol. 37, pp. 651- 656 ,(1997) , 10.1046/J.1537-2995.1997.37697335162.X
Peer B. Christensen, Niels Fisker, Lone H. Mygind, Henrik B. Krarup, Niels Wedderkopp, Kim Varming, J�rgen Georgsen, GB virus C epidemiology in Denmark: different routes of transmission in children and low- and high-risk adults. Journal of Medical Virology. ,vol. 70, pp. 156- 162 ,(2003) , 10.1002/JMV.10359
Huey-Ling Chen, Mei-Hwei Chang, Ho-Hsiung Lin, Yen-Hsuan Ni, Hong-Yuan Hsu, Jin-Town Wang, Ding-Shinn Chen, None, Antibodies to E2 protein of hepatitis G virus in children: Different responses according to age at infection☆☆☆★★★ The Journal of Pediatrics. ,vol. 133, pp. 382- 385 ,(1998) , 10.1016/S0022-3476(98)70274-4
Haruki Komatsu, Tomoo Fujisawa, Ayano Inui, Tsuyoshi Sogo, Youichi Morinishi, Yoshihiro Miyagawa, Michio Inui, GBV-C/HGV infection in children with chronic hepatitis C. Journal of Medical Virology. ,vol. 59, pp. 154- 159 ,(1999) , 10.1002/(SICI)1096-9071(199910)59:2<154::AID-JMV5>3.0.CO;2-Q
Dámaso Infante, Margarita Pich, Ramon Tormo, Silvia Sauleda, Carlos Montané, Juan Ignacio Esteban, Rafael Esteban, Prevalence of hepatitis G virus in healthy children in liver disease, and human immunodeficiency virus-1 infection: Response to interferon Journal of Pediatric Gastroenterology and Nutrition. ,vol. 30, pp. 385- 390 ,(2000) , 10.1097/00005176-200004000-00007
Dj Siebert, Ds Bowden, Sl Tracy, W Hardikar, Prevalence of Hepatitis g/GBV-C in a Healthy Paediatric Population. Journal of Paediatrics and Child Health. ,vol. 38, pp. 423- 423 ,(2002) , 10.1046/J.1440-1754.2002.00029.X
Kenji Goto, Kohachiro Sugiyama, Rou Li, Yoshishige Miyake, Toshihiro Ando, Fumihiko Mizutani, Koji Terabe, Kantaro Mizuno, Yoshiro Wada, Prevalence of GB Virus C/Hepatitis G Virus Ribonucleic Acid and Anti-Hepatitis G Virus-E2 Antibodies among Japanese Children with Histories of Transfusions or with Liver Diseases Pediatric Research. ,vol. 45, pp. 128- 132 ,(1999) , 10.1203/00006450-199901000-00021