Prevalence and Clinical Significance of HGV/GBV-C Infection in Patients with Chronic Hepatitis B or C
作者： Chia-Yen Dai , Shinn-Cherng Chen , Zu-Yau Lin , Wan-Long Chuang , Ming-Yuh Hsieh
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摘要: Hepatitis G virus/GB virus-C (HGV/GBV-C) is a newly identified Flavivirus. Its clinical significance in chronic hepatitis B and C remains controversial. Infection with HGV/GBV-C was surveyed 500 blood donors, 130 patients 173 C, liver disease, cirrhosis, and/or hepatocellular carcinoma (HCC). RNA detected by reverse transcription-polymerase chain reaction. An antibody to HGV/GBV-C's second envelope protein (anti-E2 Ab) using an enzyme immunoassay. The prevalence of 3.4% the exposure rate 10.2% donors. 7.7 17.3%, respectively (P = 0.002). infection carriers increased severity disease risk HCC. age duration virus were more important contributing factors. Clinical virological characteristics comparable between those without coinfection C. seroconversion high. Coinfection or does not affect severity, but accelerates progression development
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