Prognostic value of matrix metalloproteinase-2 (MMP-2) expression in endometrial endometrioid adenocarcinoma.

摘要: Matrix metalloproteinase-2 (MMP-2), a member of the zinc-dependent metalloproteinase gene family, plays an important role in cancer invasion and metastasis. The current study aimed to evaluate whether expression MMP-2 is associated with survival patients endometrial endometrioid adenocarcinoma. immunoreactive protein was evaluated from adenocarcinoma endometrium 112 treated at Oulu University Hospital, Finland. median follow-up time 88 months. studied immunohistochemically paraffin-embedded tissue samples primary tumours by using specific monoclonal antibody MMP-2. found 80% tumours, including all histological grades. All grade 3 tumors were MMP-2-positive. At end period, 21 22 (95%) presenting MMP-2-negative immunostaining alive, whereas corresponding figure for those MMP-2-positive 78 out 90 (87%). These data suggest that negativity might be linked favourable prognosis Endometrial carcinoma one most common malignancies female genital tract Western countries. Endometrioid accounts 60-80% types cancers, depth myometrial prognostic factors this disease. It generally considered relatively low-risk malignancy because majority cases are diagnosed International Federation Gynecology Obstetrics (FIGO) stage I have prognosis. Tumour metastasis major causes treatment failure or death among patients. matrix metalloproteinases (MMPs) tumour metastasis, as well angiogenesis, important. (MMP-2, gelatinase A, type IV collagenase) belongs family metalloendoproteinases degrade proteins collagen other extracellular macromolecules. has been invasiveness several human neoplasias, such ovarian (1, 2), breast colon (3) melanoma (4, 5). In types, protein, its mRNA, predicts poor literature regarding is, however, rather scant. present designed assess patient outcome compare conventional clinical histopathological parameters, especially invasion.