Unexpected single-year-of-age changes in the elderly mortality rate in England and Wales during 2012.

摘要: Aims: To evaluate single-year-of-age specificity in deaths England and Wales associated with a large, unexpected unexplained increase 2012. demonstrate that this type of event has occurred previously across the entire UK. infectious-like spread at regional level may be involved. Study Design: Longitudinal study annual (calendar year) (all-cause mortality) United Kingdom using publically available statistics from Office for National Statistics (ONS). Place Duration Study: Kingdom, & Wales, local authorities within covering variety time spans designed to illustrate various key points. Methodology: Deaths between 1974 2012 Kingdom. Live population residents English authorities. Calculation death rates 2011 which are years before after large deaths. Results: A recurring series events can demonstrated prior 2000 had been largely assumed due influenza epidemics. The shows elderly particularly above age 75, is somewhat expected given increased susceptibility environment as we age. single year mortality rate saw tooth behavior even more exaggerated seen difference Similar standardized admissions Original Research Article British Journal Medicine Medical Research, 4(16): 3196-3207, 2014 3197 via emergency department 2008 infectious behind phenomenon illustrated probably results 40% underestimation behavior. Conclusion: known what called ‘original antigenic sin’. Hence appears indicate high was an outbreak agent multiple strains. This confirms other studies investigating simultaneous medical hospital during increase. ubiquitous herpes virus, cytomegalovirus involved, although moment virus provides prototype sort immune modulating responsible. use five bands standardize admission subject misleading outcomes where periodicity these outbreaks their cumulative effect on mediated responses out synchrony basic both rates. major implication calculation (HSMR).