Drug discovery in prostate cancer mouse models
作者： Kenneth C Valkenburg , Kenneth J Pienta
DOI: 10.1517/17460441.2015.1052790
关键词:
摘要: Introduction: The mouse is an important, though imperfect, organism with which to model human disease and discover test novel drugs in a preclinical setting. Many experimental strategies have been used new biological molecular targets the mouse, hopes of translating these discoveries into treat prostate cancer humans. Modeling however, has challenging, often that work mice failed trials.Areas covered: authors discuss similarities differences between men; types models exist cancer; practical questions one must ask when using as model; potential reasons do not translate They also current value for drug discovery what needs are still unmet field.Expert opinion: With proper planning following guidelines by researcher...
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