TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia.
作者： N. A. Bhowmick
关键词:
摘要: Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor-beta (TGF-beta) signaling such epithelial-mesenchymal interactions was determined by conditional inactivation TGF-beta type II receptor gene mouse fibroblasts (Tgfbr2fspKO). loss responsiveness resulted intraepithelial neoplasia prostate and invasive squamous cell carcinoma forestomach, both associated with an increased abundance stromal cells. Activation paracrine hepatocyte factor (HGF) identified as one possible mechanism for stimulation epithelial proliferation. Thus, modulates oncogenic potential epithelia selected tissues.
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