Binding of Transforming Growth Factor-β to Cell Surface Proteins Varies with Cell Type
作者： Patricia R. Segarini , David M. Rosen , Saeid M. Seyedin
DOI: 10.1210/MEND-3-2-261
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摘要: Transforming growth factor-β (TGFβ1 and TGFβ2) bind to several different cell surface proteins, including a high Mr proteoglycan. We found that on primary early passage cultures of fibroblasts, chondroblasts, osteoblasts TGFβ1 binds both the proteoglycan lower components, whereas epithelial, endothelial, lymphoid-derived cells only species. With lines, this distinction is lost. Further analysis indicated binding not necessary for induced regulation DNA, collagen fibronectin synthesis, change in morphology, or reorganization actin cytoskeleton. propose components are active receptors mediating these events
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endojournals.org参考文章(56)
A Woods, JR Couchman, S Johansson, M Höök, None, Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments. The EMBO Journal. ,vol. 5, pp. 665- 670 ,(1986) , 10.1002/J.1460-2075.1986.TB04265.X
S M Seyedin, A Y Thompson, H Bentz, D M Rosen, J M McPherson, A Conti, N R Siegel, G R Galluppi, K A Piez, Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta. Journal of Biological Chemistry. ,vol. 261, pp. 5693- 5695 ,(1986) , 10.1016/S0021-9258(17)38436-3
J E Koda, A Rapraeger, M Bernfield, Heparan sulfate proteoglycans from mouse mammary epithelial cells. Cell surface proteoglycan as a receptor for interstitial collagens. Journal of Biological Chemistry. ,vol. 260, pp. 8157- 8162 ,(1985) , 10.1016/S0021-9258(17)39576-5
P R Segarini, S M Seyedin, The high molecular weight receptor to transforming growth factor-beta contains glycosaminoglycan chains. Journal of Biological Chemistry. ,vol. 263, pp. 8366- 8370 ,(1988) , 10.1016/S0021-9258(18)68486-8
S.M. Seyedin, P.R. Segarini, D.M. Rosen, A.Y. Thompson, H. Bentz, J. Graycar, Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta. Journal of Biological Chemistry. ,vol. 262, pp. 1946- 1949 ,(1987) , 10.1016/S0021-9258(18)61601-1
J Massagué, Subunit structure of a high-affinity receptor for type beta-transforming growth factor. Evidence for a disulfide-linked glycosylated receptor complex. Journal of Biological Chemistry. ,vol. 260, pp. 7059- 7066 ,(1985) , 10.1016/S0021-9258(18)88887-1
P R Segarini, A B Roberts, D M Rosen, S M Seyedin, Membrane binding characteristics of two forms of transforming growth factor-beta. Journal of Biological Chemistry. ,vol. 262, pp. 14655- 14662 ,(1987) , 10.1016/S0021-9258(18)47846-5
R A Ignotz, J Massagué, Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. Journal of Biological Chemistry. ,vol. 261, pp. 4337- 4345 ,(1986) , 10.1016/S0021-9258(17)35666-1
J R Florini, A B Roberts, D Z Ewton, S L Falen, K C Flanders, M B Sporn, Transforming growth factor-beta. A very potent inhibitor of myoblast differentiation, identical to the differentiation inhibitor secreted by Buffalo rat liver cells. Journal of Biological Chemistry. ,vol. 261, pp. 16509- 16513 ,(1986) , 10.1016/S0021-9258(18)66595-0
R K Assoian, A Komoriya, C A Meyers, D M Miller, M B Sporn, Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. Journal of Biological Chemistry. ,vol. 258, pp. 7155- 7160 ,(1983) , 10.1016/S0021-9258(18)32345-7