Receptors for transforming growth factor-beta.
作者： Kohei Miyazono , Peter Ten Duke , Hidenori Ichijo , Carl-Henrik Heldin
DOI: 10.1016/S0065-2776(08)60510-6
关键词:
摘要: Publisher Summary This chapter focuses on the mechanisms of action transforming growth factor- β (TGF- ) and related factors, in particular their interaction with specific receptors binding proteins. TGF- was initially purified from human platelets as a 25-kDa homodimeric peptide using ability factor to confer morphological transformation anchorage-independent normal rat kidney (NRK) fibroblasts an assay. The biological effects that are mediated by include regulation cell proliferation, differentiation, adhesion, migration; stimulation extracellular matrix (ECM) deposition; modulation many inflammatory immune responses. has been proposed have important vivo physiological roles tissue recycling, wound repair, morphogenesis during embryogenic development. Three distinct isoforms identified mammals; denoted TGF 1, 2, 3, they exert similar, but not identical, activities vitro well vivo. cellular is through surface receptors. carefully controlled. s secreted cells latent forms activated under certain conditions.
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