The role of B cell and pre-B-cell receptors in development and growth control of the B-lymphocyte cell lineage

摘要: Publisher Summary This chapter discusses the roles of B-cell receptor or immunoglobulins (Ig and Ig-like molecules) T-cell receptors to control specificity clonal selection immune responses lymphocytes. Binding antigen pre-existing Ig on lymphocytes determines an response. There are five major molecules surface B-lymphocyte lineage cell that changes with development lineage. Resting can be positively activated by two ways proliferate mature into Ig-secreting cells. The also reviews continuation completion cycle a proliferating B-cell. Self-reactive B-cells high avidity arise as somatic mutants clone is induced in helper T-cell-dependent response foreign antigen. Moreover, schemes controlling mechanisms developed applicable pool short-lived, primary, virgin, IgM IgD expressing, antigen-sensitive Two distinct apparent signaling T-dependent T-independent antigens.