Experimental simvastatin-induced myopathy in rabbits
作者： Keiichi Nakahara , Masaru Kuriyama , Hiroaki Yoshidome , Kazuya Nagata , Tatsui Nagado
DOI: 10.1016/0022-510X(92)90273-N
关键词:
摘要: We induced experimental myopathy in rabbits by giving simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. After oral administration of simvastatin (50 mg/kg/day) for 2 weeks, serum CK was elevated 5 7 rabbits; degenerating or necrotic fibers were seen 3 rabbits. Using electromyography, myotonic discharges found the examined. The combination discharges, necrosis and raised levels suggests that lesions muscle surface membrane.
elsevier.com
sci-hub.se 参考文章(22)
Victor Dubowitz, Muscle biopsy: A modern approach ,(1973)
M S Schwartz, R J Stubbs, J I Germershausen, R S Eydelloth, S J Grossman, P H Kari, K P Vyas, J S MacDonald, P F Smith, HMG-CoA reductase inhibitor-induced myopathy in the rat: cyclosporine A interaction and mechanism studies. Journal of Pharmacology and Experimental Therapeutics. ,vol. 257, pp. 1225- 1235 ,(1991)
J. B. Peter, W. Fiehn, Diazacholesterol myotonia: accumulation of desmosterol and increased adenosine triphosphatase activity of sarcolemma. Science. ,vol. 179, pp. 910- 912 ,(1973) , 10.1126/SCIENCE.179.4076.910
N. Winer, D. M. Klachko, R. D. Baer, P. L. Langley, T. W. Burns, Myotonic Response Induced by Inhibitors of Cholesterol Biosynthesis Science. ,vol. 153, pp. 312- 313 ,(1966) , 10.1126/SCIENCE.153.3733.312
Paola Tonin, Paulette Lewis, Serenella Servidei, Salvatore Dimauro, Metabolic causes of myoglobinuria. Annals of Neurology. ,vol. 27, pp. 181- 185 ,(1990) , 10.1002/ANA.410270214
Hubert Kwiecińaski, Frank Lehmann-Horn, Reinhardt Rüdel, Drug-induced myotonia in human intercostal muscle Muscle & Nerve. ,vol. 11, pp. 576- 581 ,(1988) , 10.1002/MUS.880110609
Geraldine Mantell, M.Theresa Burke, Joan Staggers, Extended clinical safety profile of lovastatin. American Journal of Cardiology. ,vol. 66, ,(1990) , 10.1016/0002-9149(90)90435-4
TIBOR BARKA, PAUL J ANDERSON, None, HISTOCHEMICAL METHODS FOR ACID PHOSPHATASE USING HEXAZONIUM PARAROSANILIN AS COUPLER Journal of Histochemistry and Cytochemistry. ,vol. 10, pp. 741- 753 ,(1962) , 10.1177/10.6.741
Jonathan A. Tobert, Efficacy and long-term adverse effect pattern of lovastatin American Journal of Cardiology. ,vol. 62, ,(1988) , 10.1016/0002-9149(88)90004-5
A.M. Pierides, F. Alvarez-Ude, D.N.S. Kerr, A.W. Skillen, CLOFIBRATE-INDUCED MUSCLE DAMAGE IN PATIENTS WITH CHRONIC RENAL FAILURE The Lancet. ,vol. 306, pp. 1279- 1282 ,(1975) , 10.1016/S0140-6736(75)90613-3