Microscopic and electrophysiological changes on regenerating sciatic nerves of rats treated with simvastatin.
作者： Aykut Erbengi , Mustafa Berker , Mehmet Demirci , Mürvet Tuncel , Erdem Karabulut
DOI:
关键词: Myelinated nerve fiber 、 Chemistry 、 Anatomy 、 Axoplasm 、 Pathology 、 Sciatic nerve 、 Peripheral neuropathy 、 Vacuolization 、 Sciatic nerve injury 、 Myelin 、 Simvastatin
摘要: … In this study simvastatin was shown to delay regeneration of the nerve fibers in microscopic studies. However we could not prove this finding on electrophysiological measurements. …
参考文章(13)
PAUL E. ZIAJKA, TAMMY WEHMEIER, Peripheral Neuropathy and Lipid-Lowering Therapy Southern Medical Journal. ,vol. 91, pp. 667- 668 ,(1998) , 10.1097/00007611-199807000-00013
Y.L. Lo, T.H. Leoh, L.M. Loh, C.E. Tan, Statin therapy and small fibre neuropathy: a serial electrophysiological study. Journal of the Neurological Sciences. ,vol. 208, pp. 105- 108 ,(2003) , 10.1016/S0022-510X(02)00396-9
Peter S. Spencer, A. R. Lieberman, Scanning electron microscopy of isolated peripheral nerve fibres. Normal surface structure and alterations proximal to neuromas. Cell and Tissue Research. ,vol. 119, pp. 534- 551 ,(1971) , 10.1007/BF00455247
Mimoun Azzouz, Philippe F. Kennel, Jean-Marie Warter, Philippe Poindron, Jacques Borg, Enhancement of Mouse Sciatic Nerve Regeneration by the Long Chain Fatty Alcohol,N-Hexacosanol Experimental Neurology. ,vol. 138, pp. 189- 197 ,(1996) , 10.1006/EXNR.1996.0057
Keiichi Nakahara, Masaru Kuriyama, Yoshito Sonoda, Hiroaki Yoshidome, Hiroto Nakagawa, Jiro Fujiyama, Itsuro Higuchi, Mitsuhiro Osame, Myopathy Induced by HMG–CoA Reductase Inhibitors in Rabbits: A Pathological, Electrophysiological, and Biochemical Study☆ Toxicology and Applied Pharmacology. ,vol. 152, pp. 99- 106 ,(1998) , 10.1006/TAAP.1998.8491
Keiichi Nakahara, Masaru Kuriyama, Hiroaki Yoshidome, Kazuya Nagata, Tatsui Nagado, Masanori Nakagawa, Kimiyoshi Arimura, Itsuro Higuchi, Mitsuhiro Osame, Experimental simvastatin-induced myopathy in rabbits Journal of the Neurological Sciences. ,vol. 113, pp. 114- 117 ,(1992) , 10.1016/0022-510X(92)90273-N
T Phan, J G McLeod, J D Pollard, O Peiris, A Rohan, J P Halpern, Peripheral neuropathy associated with simvastatin. Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 58, pp. 625- 628 ,(1995) , 10.1136/JNNP.58.5.625
Peter M. Bridge, Douglas J. Ball, Susan E. Mackinnon, Yasushi Nakao, Keith Brandt, Daniel A. Hunter, Catherine Hertl, Nerve crush injuries--a model for axonotmesis Experimental Neurology. ,vol. 127, pp. 284- 290 ,(1994) , 10.1006/EXNR.1994.1104
Pang H. Chong, Alexandra Boskovich, Natasa Stevkovic, Russell E. Bartt, Statin-associated peripheral neuropathy: review of the literature. Pharmacotherapy. ,vol. 24, pp. 1194- 1203 ,(2004) , 10.1592/PHCO.24.13.1194.38084
Yusuf A. Rajabally, Vivek Varakantam, Richard J. Abbott, Disorder resembling Guillain-Barré syndrome on initiation of statin therapy. Muscle & Nerve. ,vol. 30, pp. 663- 666 ,(2004) , 10.1002/MUS.20112