Statin-associated peripheral neuropathy: review of the literature.

摘要: Various pharmacologic agents are available for the treatment of hypercholesterolemia, including 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, commonly referred to as statins, which offer favorable lipid-lowering effects and reductions in morbidity mortality. Statins usually better tolerated than other therefore have become a mainstay hypercholesterolemia. However, recent case reports peripheral neuropathy patients treated with statins may gone unnoticed by health care professionals. To evaluate possible link between neuropathy, literature searches using MEDLINE (January 1993--November 2003) International Pharmaceutical Abstracts 1970--June 2002) were performed. Key search terms statin, HMG-CoA inhibitors. Based on epidemiologic studies well reports, risk associated statin use exist; however, appears be minimal. On hand, benefits firmly established. These findings should alert prescribers potential receiving any statins; that is, considered cause when etiologies been excluded.