The mechanisms of lethal action of arabinosyl cytosine (araC) and arabinosyl adenine (araA)
作者： Seymour S. Cohen
DOI: 10.1002/1097-0142(197707)40:1+<509::AID-CNCR2820400717>3.0.CO;2-8
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摘要: Certain D-arabinosyl nucleosides, notably arabinosyl cytosine (araC) and adenine (araA), are useful in the treatment of certain leukemias some DNA virus infections, respectively. The compounds lethal to animal cells bacteria. Despite extensive deamination, parent nucleosides transported within sensitive phosphorylated mono-, di- triphosphates. AraCTP araATP good specific competitive inhibitors tumor cell virus-induced polymerases, competing with dCTP dATP In addition markedly inhibiting synthesis, aranucleotides enter newly formed internucleotide linkage. Sensitivity appears correlate relative ratio formation triphosphate via a nucleoside kinase degradation deaminase. Inhibition deaminase increases aranucleoside leukemic or virus-infected toxicity nucleosides. Combinations deaminases being explored clinical situations. addition, slow penetration into has been observed these 5'-phosphates antiviral agents, e.g., against herpes herpetic kiratitis.
sci-hub.se 参考文章(58)
V. G. Malathi, Ivan K. Rothman, Robert Silber, Nucleoside deaminase activity in viral leukemia. Cancer Research. ,vol. 31, pp. 274- 276 ,(1971)
David G. Johns, Richard H. Adamson, Enhancement of the biological activity of cordycepin (3'-deoxyadenosine) by the adenosine deaminase inhibitor 2'-deoxycoformycin. Biochemical Pharmacology. ,vol. 25, pp. 1441- 1444 ,(1976) , 10.1016/0006-2952(76)90121-0
J. J. Furth, Seymour S. Cohen, Inhibition of Mammalian DNA Polymerase by the 5′-Triphosphate of 1-β-d-Arabinofuranosylcytosine and the 5′-Triphosphate of 9-β-d-Arabinofuranosyladenine Cancer Research. ,vol. 28, pp. 2061- 2067 ,(1968)
J. S. Evans, E. A. Musser, G. D. Mengel, K. R. Forsblad, J. H. Hunter, Antitumor Activity of 1-β-D-Arabinofuranosylcytosine Hydrochloride Experimental Biology and Medicine. ,vol. 106, pp. 350- 353 ,(1961) , 10.3181/00379727-106-26335
Alexander Baumgarten, Combined Immunodeficiency Disease and Adenosine Deaminase Deficiency. A Molecular Defect Yale Journal of Biology and Medicine. ,vol. 49, pp. 312- 312 ,(1976)
Priscilla J. Ortiz, The inhibition of E. coli adenyl cyclase by ara ATP. Biochemical and Biophysical Research Communications. ,vol. 46, pp. 1728- 1733 ,(1972) , 10.1016/0006-291X(72)90809-1
WERNER. BERGMANN, DEREK C. BURKE, CONTRIBUTIONS TO THE STUDY OF MARINE PRODUCTS. XXXIX. THE NUCLEOSIDES OF SPONGES. III.1 SPONGOTHYMIDINE AND SPONGOURIDINE2 Journal of Organic Chemistry. ,vol. 20, pp. 1501- 1507 ,(1955) , 10.1021/JO01128A007
Naishun C. Yung, Joseph H. Burchenal, Ronald Fecher, Robert Duschinsky, Jack J. Fox, Nucleosides. XI. Synthesis of 1-β-D-Arabinofuranosul-5-Fluorouracil and Related Nucleosides1 Journal of the American Chemical Society. ,vol. 83, pp. 4060- 4065 ,(1961) , 10.1021/JA01480A026
G. E. Underwood, Activity of 1-beta-D-arabinofuranosylcytosine hydrochloride against herpes simplex keratitis. Experimental Biology and Medicine. ,vol. 111, pp. 660- 664 ,(1962) , 10.3181/00379727-111-27884
William W. Lee, Allen Benitez, Leon Goodman, B. R. Baker, POTENTIAL ANTICANCER AGENTS.1 XL. SYNTHESIS OF THE β-ANOMER OF 9-(D-ARABINOFURANOSYL)-ADENINE Journal of the American Chemical Society. ,vol. 82, pp. 2648- 2649 ,(1960) , 10.1021/JA01495A070