Dental and periodontal phenotype in sclerostin knockout mice.

摘要: Sclerostin is a Wnt signalling antagonist that controls bone metabolism. expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear. Here, we analysed mandibles sclerostin knockout mice to determine influence on dimensions using histomorphometry micro-computed tomography (μCT) imaging. μCT histomorphometric analyses were performed first lower molar surrounding lacking functional gene wild-type controls. six animals each group revealed dimension basal as well coronal apical part alveolar increased mice. No significant differences observed for tooth pulp chamber volume. Descriptive four three demonstrated an width cementum concomitant moderate decrease periodontal space width. Taken together, these results suggest lack mainly alters phenotypes rather than producing abnormalities such dentin.