Critical roles of periostin in the process of orthodontic tooth movement

摘要: Aim: The process of orthodontic tooth movement (OTM) involves multiple mechanisms action including bone and extracellular matrix remodelling, although the role periodontal ligament (PDL) in this is largely unknown. Periostin, which highly expressed PDL, known to be responsible for mechanical stimulation maintaining integrity tissues. We hypothesize that protein plays an important during OTM. Material methods: By using spring 4-week-old wild-type (WT) periostin null mice, rate mineralization were evaluated. For evaluation, double labelling, expression sclerostin (SOST), number TRAP-positive cells, quality collagen fibrils by Sirius red analysed compared between these two groups. Results: Our findings showed distance mineral deposition rates significantly reduced mice ( P < 0.05), with a lack changes SOST as observed WT group. arrangement, digestion, impaired mice. osteoclasts reflected expressions TRAP (tartrate-resistant acid phosphatase) was also lower than control 0.05). Conclusion: Periostin stimulatory both responses OTM compassion site, it not clear if direct or indirect loading.