Vitamin D: extraskeletal health.

摘要: Vitamin D deficiency is the most common nutritional and likely medical condition in world. There a multitude of causes vitamin deficiency, but major cause has been lack appreciation that body requires 5- to 10-fold higher intakes than currently recommended by Institute Medicine other health agencies. It our hunter gatherer fore-fathers being exposed sunlight on daily basis were making several thousand IU day. The fact 100 prevented overt signs rickets led false security ingesting twice this amount was more adequate satisfy body’s requirement. Although may be true for preventing skeletal deformities associated with rickets, there now overwhelming compelling scientific epidemiologic data suggesting human blood level 25(OH)D above 30 ng/mL maximum health. reason essentially every tissue cell VDR thus, have enough all these cellular requirements, needs ng/mL. estimated ingested increases 1 Thus theoretically achieve ingestion 3000 evidence, however, when levels are less 15 ng/mL, able efficiently use raise about 20 To 1-ng increase; therefore increase minimum at least 1000 day adults. great need significantly D. All neonates during first year life should take 400 IU/d D, increasing it provide additional benefits. Children older as recently American Academy Pediatrics, they consider intake up 2000 derive benefits from Prepubertal teenage girls who received per showed improvement their musculoskeletal no untoward toxicity. adults taking A recent study reported took 50,000 once 2 weeks, which equivalent day, 6 years effective maintaining between 40 60 without any downside either child’s or adult’s intake, exception acquired disorders such granulomatous diseases including sarcoidosis tuberculosis, well some lymphomas activated macrophages produce 1,25(OH)2D3 an unregulated fashion.