Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes and Parkinson's disease
作者： David L. Coffen , Rex T. Weavers , Thomas P. Lake , David S. Larsen , Gerardo M. Castillo
DOI:
关键词:
摘要: Bis- and tris-dihydroxyaryl compounds their methylenedioxy analogs pharmaceutically acceptable esters, synthesis, pharmaceutical compositions containing them, use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed Alzheimer's disease, IAPP type 2 diabetes, synucleinopathies, Parkinson's manufacture medicaments for treatment.
lens.org参考文章(212)
Dietmar Baumann, Sven Adler, Matthias Hamburger, A simple isolation method for the major catechins in green tea using high-speed countercurrent chromatography Journal of Natural Products. ,vol. 64, pp. 353- 355 ,(2001) , 10.1021/NP0004395
I. Grundke-Iqbal, K. Iqbal, Y. C. Tung, M. Quinlan, H. M. Wisniewski, L. I. Binder, Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 4913- 4917 ,(1986) , 10.1073/PNAS.83.13.4913
Ben Zhang, Gen-ichiro Nonaka, Itsuo Nishioka, Potentillanin, a biflavanoid and a procyanidin glycoside from Potentilla viscosa☆ Phytochemistry. ,vol. 27, pp. 3277- 3280 ,(1988) , 10.1016/0031-9422(88)80042-6
Zofia Czochanska, Lai Yeap Foo, Roger H. Newman, Lawrence J. Porter, Wayne A. Thomas, William T. Jones, Direct proof of a homogeneous polyflavan-3-ol structure for polymeric proanthocyanidins Journal of The Chemical Society, Chemical Communications. pp. 375- 377 ,(1979) , 10.1039/C39790000375
Toshiaki Kamei, Tokuhiro Ishihara, Shigeyoshi Fujihara, Hidenori Nakamura, Tadaaki Yokota, Naoki Imada, Shin'ichiro Akizuki, Takako Iwata, Fumiya Uchino, AMYLOIDOSIS ASSOCIATED WITH JUVENILE RHEUMATOID ARTHRITIS Pathology International. ,vol. 32, pp. 123- 133 ,(1982) , 10.1111/J.1440-1827.1982.TB02033.X
Alan D. Snow, David Nochlin, Raymond Sekiguchi, Steven S. Carlson, Identification and Immunolocalization of a New Class of Proteoglycan (Keratan Sulfate) to the Neuritic Plaques of Alzheimer's Disease Experimental Neurology. ,vol. 138, pp. 305- 317 ,(1996) , 10.1006/EXNR.1996.0069
J. F. Flood, J. E. Morley, E. Roberts, Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 3363- 3366 ,(1991) , 10.1073/PNAS.88.8.3363
C. L. Masters, G. Simms, N. A. Weinman, G. Multhaup, B. L. McDonald, K. Beyreuther, Amyloid plaque core protein in Alzheimer disease and Down syndrome Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 4245- 4249 ,(1985) , 10.1073/PNAS.82.12.4245
William M. Pardridge, Harry V. Vinters, Jing Yang, Jody Eisenberg, Thomas B. Choi, Wallace W. Tourtellotte, Verena Huebner, John E. Shively, Amyloid Angiopathy of Alzheimer's Disease: Amino Acid Composition and Partial Sequence of a 4,200‐Dalton Peptide Isolated from Cortical Microvessels Journal of Neurochemistry. ,vol. 49, pp. 1394- 1401 ,(1987) , 10.1111/J.1471-4159.1987.TB01005.X
M. G. Spillantini, R. A. Crowther, R. Jakes, M. Hasegawa, M. Goedert, α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 6469- 6473 ,(1998) , 10.1073/PNAS.95.11.6469