Mild Intraoperative Hypothermia during Surgery for Intracranial Aneurysm

摘要: background Surgery for intracranial aneurysm often results in postoperative neurologic deficits. We conducted a randomized trial at 30 centers to determine whether intraoperative cooling during open craniotomy would improve the outcome among patients with acute aneurysmal subarachnoid hemorrhage. methods A total of 1001 preoperative World Federation Neurological Surgeons score I, II, or III (“good-grade patients”), who had hemorrhage no more than 14 days before planned surgical clipping, were randomly assigned hypothermia (target temperature, 33°C, use surface techniques) normothermia 36.5°C). Patients followed closely postoperatively and examined approximately 90 after surgery, which time Glasgow Outcome Score was assigned. There significant differences between group duration stay intensive care unit, length hospitalization, rates death follow-up (6 percent both groups), destination discharge (home another hospital, surviving patients). At final follow-up, 329 499 1 (good outcome), as compared 314 501 (66 vs. 63 percent; odds ratio, 1.14; 95 confidence interval, 0.88 1.48; P = 0.32). Postoperative bacteremia common (5 3 percent, P=0.05). conclusions Intraoperative did not good-grade