Isobenzothiazolone chromogenic thiol indicators and their derivatives

摘要: The present invention involves a newly synthe­sized chromogenic thiol-indicating isobenzothia­zolone derivative having the structure: In this structure at least one of R¹ and R² is preferably nitro, arylazo, substituted benzylideneamino or benzylideneamino. When only so substituted, may be hydrogen. R³ substituent alkyl, carboxyalkyl, hydroxyalkyl, aminoalkyl, haloalkyl, aryl, carboxyaryl, hydroxyaryl, aminoaryl, heteroaryl, carboxyheteroaryl, hydroxyheteroaryl, aminoheteroaryl, hydroxy, alkoxy, amino. A central utility compounds their use in detec­tion thiols. Thus, com­prises process for measuring presence appearance thiols, particularly an aqueous system. This comprises contacting said system with isobenzothiazolone as described herein. Chromophoric changes due to thiol-mediated reduction then occur. Such can solution on indicator surface contact been chromophoric changes, bathochromic shift characteristic light absorption upon derivative, are proportional amount rate thiols