Contribution of Haemophilus influenzae type b lipopolysaccharide to pathogenesis of infection

摘要: Abstract The mechanism(s) by which the lipopolysaccharide (LPS) of Haemophilus influenzae type b may contribute to virulence this organism is unclear. Purified LPS or phosphate buffered saline was administered intranasally infant rats prior intranasal instillation approximately 2–20 × 10 6 cfu Hib two three times per day for consecutive days. preadministration 2.0 μg resulted in a significantly greater incidence bacteremia ( P = 0.0006) than PBS 30 min after completion inoculations. Four days following inoculation 0.017) animals pretreated with at compared animals. Preadministration 0.2 had no effect on meningitis. There were differences histology nasal cavities turbinates inoculated only PBS. frequency density administration from either E. coli . Although mechanism unknown, our findings suggest that ability H. invade mucosa rat model.