Pathogenesis of bloodstream invasion with Haemophilus influenzae type b.

摘要: Possible route(s) by which encapsulated bacteria invade the blood from nasopharynx include (i) direct invasion of submucosal vessels and (ii) clearance via lymphatics to regional nodes followed bloodstream invasion. These possibilities were investigated in rats after intranasal inoculation with 10(5) Haemophilus influenzae type b. Within 24 h inoculation, 10 42 sterile cultures had similar numbers H. b recovered both cervical (local) periiliac (distant) lymph nodes, suggested early bacteremic spread. When virtually continuous obtained for 30 min 10(8) b, transient bacteremia was documented four eight rats. Also, we found no significant difference among whose been removed surgically compared sham-operated findings favor hypothesis a rapid, perhaps pharyngeal as an initial determinant systemic spread