A murine model of asbestosis.

摘要: Balb/c mice were exposed to aerosolized chrysotile fibers and evaluated as a host for the study of asbestos-induced pulmonary disease. Histologically, an initial macrophage reaction was found progress "asbestos body" formation diffuse focal interstitial fibrosis within 1 year chronic exposure period. This most intense in areas adjacent respiratory bronchioles alveolar ducts. Two morphologically distinct tumors at visceral surface also discovered among high percentage asbestos-exposed mice. Bronchoalveolar lavage demonstrated eventual alteration retrievable cell populations dusted animals. Evaluation systemic B-lymphocyte activity suggested stimulation this subset following inhalation. These results demonstrate that subsequent asbestos exposure, mouse develops immunologic changes very similar those noted human asbestosis.