The role of tetramerization in p53 function

摘要: The tumour suppressor gene p53 is extensively studied for its importance in cancer. In active conformation, tetrameric and one domain - the tetramerization permits oligomerization of this protein. Until recently, little attention was given to because, contrast DNA-binding domain, it not often mutated However, various experimental studies have shown evidence that essential DNA binding, protein-protein interactions, post-translational modifications, degradation. Moreover, single mutations can inactivate wild-type protein a manner similar seen with domain. Interestingly, phenotype several mutants differs from observed mutants. review, current knowledge about function will be summarized.