Study of deoxynivalenol effect on metallothionein and glutathione levels, antioxidant capacity, and glutathione-S-transferase and liver enzymes activity in rats

摘要: Deoxynivalenol (DON, vomitoxin) is one of several human mycotoxins acquired through residues in foods plant origin (cereals) and animal (kidneys, liver, milk, eggs). The aim this study was to investigate the impact deoxynivalenol-contaminated mouldy grain on health status rats their ability resist oxidative stress. were fed a diet supplemented with DON along organic inorganic Zn(II), vitamins for 28 days. focuses particularly protective mechanisms levels reduced glutathione metallothioneins (MT) against adverse effects xenobiotics. highest concentrations MT detected tissues kidneys ((6.70 ± 0.05) μg g−1) liver ((6.00 g−1), both which are involved detoxifying cationic Lower also heart, brain, testes, muscle (approximately 3.0 g−1). Antioxidant capacity, glutathione-S-transferase, enzymes activity studied. In conclusion, may play an important role detoxification mycotoxins. Even though its not fully understood, crucial redistribution ions transcription factors interaction reactive oxygen species that form