Preparation of highly cross-linked raspberry-like nano/microspheres and surface tailoring for controlled immunostimulating peptide adsorption

摘要: The surface functionalities of nanomaterials provide an invaluable resource to biomaterials science in the form biomolecular recognition, sensing, self-assembly and drug delivery. This paper presents a one-step procedure for facile preparation highly cross-linked raspberry-like nano/microspheres by dispersion polymerization polyethylene glycol dimethacrylate N-vinylimidazole. Ionic liquid-functionalized reactions were then conducted on investigate effects functional groups peptide adsorption aqueous media. Various characterization methods employed characterize as-prepared track experiment process. results reveal that raspberry-like, monodisperse stable. It was also found immunostimulating hexapeptide from human (IHH) correlated with properties ionic nano/microspheres, which demonstrated their potential use immobilization release IHH practical application.