Heat Shock Protein-Peptide Interaction: Basis for a New Generation of Vaccines Against Cancers and Intracellular Infections

摘要: The observations that inbred mice and rats can be immunized against their own tumors or of the same genetic background were convincingly made between 1943 1962 (Gross 1943; Foley 1953; Prehn Main 1957; Klein et al. 1960; Old 1962, for review, see Srivastava 1988). They provided underpinnings idea immunogenicity cancers by deduction, existence tumor-specific antigens. These studies showed vaccinated with inactivated cancer cells are immune to subsequent challenges live cells. phenomenon was shown individually tumor-specific, in resistant specifically which used immunize them not other (Basombrio 1970; Globerson Feldman 1964), hence name distinct tumor rejection demonstration led a search cancer-derived molecules, elicit resistance challenges. general structure these experiments fractionate proteins test ability from fractions prepared (see 1988; 1981, Boon 1992 approaches identification antigens). 96kDa, 90kDa 70kDa size identified method (Table 1; Das 1984; 1986; Ullrich Udono 1993) turned out related class known as heat shock (hsps) stress-induced Lindquist Craig Similar intact cells, it hsps gp96, hsp90 hsp70 isolated able protective immunity isolated. Hsps normal tissues found unable immunitv any tested.