Synthesis, DNA cleavage and antimicrobial activity of 4-thiazolidinones-benzothiazole conjugates.

摘要: Antimicrobial screening of several novel 4-thiazolidinones with benzothiazole moiety has been performed. These compounds were evaluated for antimicrobial activity against a panel bacterial and fungal strains. The strains treated these derivatives at varying concentrations, MIC’s calculated. Structures have determined by spectroscopic studies viz., FT-IR, 1 H NMR, 13 C NMR elemental analysis. Significant was observed some members the series, viz. 3-(4-(benzo[d]thiazol-2-yl) phenyl)-2-(4-methoxyphenyl)thiazolidin-4-one 3-(4-(benzo[d]thiazol-2-yl)phenyl)-2-(4-hydroxy phenyl)thiazolidin-4one found to be most active E.coli C.albicans MIC values in range 15.6–125 µg/ml. Preliminary study structure–activity relationship revealed that electron donating groups associated thiazolidine bearing rings had great effect on contributes positively action. DNA cleavage experiments gave valuable hints supporting evidence describing mechanism action hence showed good correlation between their calculated its lethality.