Mitochondria-Mediated Oxidative Stress: Old Target for New Drugs

摘要: Abstract Oxidative stress, one of the crucial factors genomic instability, is involved in many illnesses - from DNA damage and repair (DDR) related diseases to neurological abnormalities cancer. Patients with defective DDR pathways display high level cancer predisposition at same time reveal hydrocephalia, dementias even diabetes mellitus all representing common hallmarks mitochondria-related disorders. Since mitochondria are responsible both for cell energetic metabolism reactive oxygen/nitrogen species (RO/NS) formation, mitochondrial dysfunction (MDF) play a pivotal role above Not surprisingly, RO/NS considered be primary target large spectrum compounds aiming eliminate these adverse or, contrary, enhance their presence order amplify cellular death pathways. Yet, only few chemicals have received medical appreciation mainly because questionable therapeutic values healthy states. As result, recent efforts been focused on finding drugs that improve functions or chemoprevent MDF rather than being applied as scavengers. This review addresses most progress development application such outlines some future perspectives.