The role of chronic inflammation in the development of gastrointestinal cancers: reviewing cancer prevention with natural anti-inflammatory intervention.

摘要: Inflammatory mediators alter the local environment of tumors, known as tumor microenvironment. Mechanistically, chronic inflammation induces DNA damage, but understanding this hazard may help in search for new chemopreventive agents gastrointestinal (GI) cancer which attenuate inflammation. In clinic, GI still remains a major cause cancer-associated mortality, chemoprevention with anti-inflammatory is thought to be realistic approach reduce cancer. Proton pump inhibitors, monoclonal antibodies targeting necrosis factor-alpha, anti-sense targeted smad7 and non-steroidal have been investigated their potential prevent inflammation-based Besides these, wide variety natural products also shown prevention review, authors will provide insights explain mechanistic connection between cancer, well describe feasible strategy based on treatments.