Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer
作者： Kenneth W. Kinzler , Lois L. Myeroff , James K. V. Willson , Sanford D. Markowitz , Ramon Parsons
DOI:
关键词:
摘要: The TGFβ type II receptor (RII) was found to be mutated within a polyadenine tract in 100 of 111 (90%) colorectal cancers with microsatellite instability. Other polyadenine tracts of …
aacrjournals.org
elsevier.com参考文章(14)
M Laiho, M B Weis, J Massagué, Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction. Journal of Biological Chemistry. ,vol. 265, pp. 18518- 18524 ,(1990) , 10.1016/S0021-9258(17)44782-X
Richard Fishel, Mary Kay Lescoe, M.R.S. Rao, Neal G. Copeland, Nancy A. Jenkins, Judy Garber, Michael Kane, Richard Kolodner, The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer Cell. ,vol. 75, pp. 1027- 1038 ,(1993) , 10.1016/0092-8674(93)90546-3
Yurij Ionov, Miguel A. Peinado, Sergei Malkhosyan, Darryl Shibata, Manuel Perucho, Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis Nature. ,vol. 363, pp. 558- 561 ,(1993) , 10.1038/363558A0
S. Thibodeau, G Bren, D Schaid, Microsatellite instability in cancer of the proximal colon Science. ,vol. 260, pp. 816- 819 ,(1993) , 10.1126/SCIENCE.8484122
M. A. Peinado, S. Malkhosyan, A. Velazquez, M. Perucho, Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 10065- 10069 ,(1992) , 10.1073/PNAS.89.21.10065
Jianhua Zheng, Daniel R. Knighton, Lynn F. Ten Eyck, Rolf Karlsson, N. Xuong, Susan S. Taylor, Janusz M. Sowadski, Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry. ,vol. 32, pp. 2154- 2161 ,(1993) , 10.1021/BI00060A005
S. Hanks, A. Quinn, T Hunter, The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science. ,vol. 241, pp. 42- 52 ,(1988) , 10.1126/SCIENCE.3291115
Bo Liu, Nicholas C Nicolaides, Sanford Markowitz, James KV Willson, Ramon E Parsons, Jin Jen, Nickolas Papadopolous, Päivi Peltomäki, Albert de la Chapelle, Stanley R Hamilton, Kenneth W Kinzler, Bert Vogelstein, None, Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability Nature Genetics. ,vol. 9, pp. 48- 55 ,(1995) , 10.1038/NG0195-48
Lauri A Aaltonen, Päivi Peltomäki, Fredrick S Leach, Pertti Sistonen, Lea Pylkkänen, Jukka-Pekka Mecklin, Heikki Järvinen, Steven M Powell, Jin Jen, Stanley R Hamilton, Gloria M Petersen, Kenneth W Kinzler, Bert Vogelstein, Albert De La Chapelle, Clues to the pathogenesis of familial colorectal cancer Science. ,vol. 260, pp. 812- 816 ,(1993) , 10.1126/SCIENCE.8484121
Hendrik L. De Bondt, Jody Rosenblatt, Jarmila Jancarik, Heather D. Jones, David O. Morgant, Sung-Hou Kim, Crystal structure of cyclin-dependent kinase 2. Nature. ,vol. 363, pp. 595- 602 ,(1993) , 10.1038/363595A0