Cardiovascular magnetic resonance compatible physical model of the left ventricle for multi-modality characterization of wall motion and hemodynamics

摘要: The development of clinically applicable fluid-structure interaction (FSI) models the left heart is inherently challenging when using in vivo cardiovascular magnetic resonance (CMR) data for validation, due to lack a well-controlled system where detailed measurements ventricular wall motion and flow field are available priori. purpose this study was (a) develop relevant, CMR-compatible physical model; (b) compare (LV) volume reconstructions hemodynamic obtained CMR laboratory-based experimental modalities. LV constructed from optically clear flexible silicone rubber. geometry based off healthy patient’s during peak systole. phantom attached simulator consisting an aorta, atrium, systemic resistance compliance elements. Experiments were conducted rate 70 bpm. Wall high speed stereo-photogrammetry (SP) cine-CMR, while digital particle image velocimetry (DPIV) phase-contrast (PC-CMR). model reproduced physiologically accurate hemodynamics (aortic pressure = 120/80 mmHg; cardiac output = 3.5 L/min). DPIV PC-CMR results center plane within ventricle matched, both qualitatively quantitatively, with atrium into having velocity about 1.15 m/s normalized through cycle computed matched closely that SP. mean difference between SP 5.5 ± 3.7 %. presented here can thus be used purposes of: acquiring validation FSI simulations, determining accuracy cine-CMR reconstruction methods, (c) conducting investigations effects altering anatomical variables on function under normal disease conditions.