Carcinogenicity test of polyoxyethylene(10) nonylphenyl ether (NP-10) in female B6C3F1 mice.

摘要: A carcinogenicity study of polyoxyethylene(10)nonylphenyl ether (NP-10) to B6C3F1 mouse was performed using 50 females per group 4 groups, or 200 mice in total. Diets containing NP-10 at 0, 500, 1500 and 4500 ppm were prepared orally administered the animals repeatedly for 104 weeks, observation general conditions, body weight analysis, food consumption hematologic examination, organ analysis pathological examination performed. The results are summarized as follows. mean intake test substance groups weeks 81.5, 254 873 mg/kg/day, respectively. There no differences observed mortality among did not exceed background data any groups. signs attributable administration substance, various which increased occurrence with aging all a similar frequency. Body gain suppressed only throughout entire period. Food treated around early stage and, thereafter, until mid-stage administration. Decreased efficiency alone. As result changes lower absolute weights liver kidney higher relative brain, kidney, considered be accompanying gain, group. revealed marked gross findings histological there neoplastic non-neoplastic lesions unequivocally have occurrence. above show, cause increase incidence by oral 2 years mg/kg/day (4500 ppm) determined carcinogenicity.