Effect of Gamma Knife surgery on the risk of rupture prior to AVM obliteration.

摘要: The incidence for hemorrhage in non-obliterated arteriovenous malformations (AVM) during the first two years following Gamma Knife (GK) surgery was compared to calculated untreated patients. There a decrease of as natural course. This difference statistically significant. actual number hemorrhages 49 series 1604 Additionally, 41 occurred beyond treatment over entire follow up time span 24 years. For roughly times higher than observed incidence. impact on history detectable already within six months after totally covered with at least 25 Gy. relation between high minimum and average dose one hand lower risk other Low doses age correlated risk. Neither prior nor interval presenting seemed influence post hemorrhage. permanent neurological deficit or death due AVM rupture latency period total nidus obliteration less 0.5% small 2-4% large ones Of patients sequelae 14 died 10 remained different degrees. However, all survivors were self sufficient.