Impact of prematurity, stress and sepsis on the neutrophil respiratory burst activity of neonates.

摘要: The aim of this study was to evaluate the impact prematurity, sepsis and stress on neutrophil respiratory burst activity (NRBA) neonates. For purpose 122 healthy neonates (89 term 33 preterm), preterm stressed neonates, 59 septic (12 47 preterm) 26 adults were studied. NRBA assessed after in vitro stimulation by PMA using a whole blood flow cytometric microassay with dihydrorhodamine 123 (DHR 123). It found that percentage responding neutrophils comparable (medians 83.5 89.8%, respectively), whereas it significantly lower (median 70.6%, p