Tumour-suppressive miRNA-26a-5p and miR-26b-5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer.
作者： K Miyamoto , N Seki , R Matsushita , M Yonemori , H Yoshino
DOI: 10.1038/BJC.2016.179
关键词:
摘要: Previous studies have revealed that miR-26a-5p and miR-26b-5p act as tumour suppressors in various types of cancer tissues. Here, we aimed to investigate the functional roles these miRNAs identify their regulatory targets bladder (BC). We performed assays BC cells using transfection mature microRNAs (miRNAs). In silico luciferase reporter analyses were applied target genes miRNAs. The overall survival (OS) patients with was evaluated by Kaplan–Meier method. significantly downregulated Restoration inhibited cell migration invasion BC. gene encoding procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), a collagen crosslinking enzyme, directly regulated miR-26b-5p. analysis high PLOD2 expression had shorter OS compared those low (P=0.0153). PLOD2, which is associated stiffness extracellular matrix, may be good prognostic marker
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