Behavioral effects of developmental exposure to JWH-018 in wild type and disrupted in schizophrenia 1 (disc1) mutant zebrafish

摘要: Synthetic cannabinoids can cause acute adverse psychological effects, but the potential impact when exposure happens before birth is unknown. Use of synthetic during pregnancy may affect fetal brain development, and such effects could be moderated by genetic makeup an individual. Disrupted in schizophrenia 1 (DISC1) a gene with important roles neurodevelopment which has been associated psychiatric disorders pedigree analyses. Using zebrafish as model, we investigated (1) behavioral developmental to JWH-018 (a common psychoactive cannabinoid) (2) whether disc1 moderates JWH-018. As altered anxiety responses are seen several disorders, focused on anxiety-like behavior. Zebrafish embryos were exposed from one six days post-fertilization. Anxiety-like behavior was assessed using forced light/dark acoustic startle assays larvae, novel tank diving adults. Compared controls, developmentally larvae had impaired locomotion test, levels response stimuli unaltered. Adult spent less time bottom tank, suggesting decreased anxiety. Loss-of-function increased did not alter sensitivity Results suggest zebrafish, disc1.