Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation.
作者： Emily M. Martinez , Miya C. Yoshida , Tara Lynne T. Candelario , Millie Hughes-Fulford
DOI: 10.1152/AJPREGU.00449.2014
关键词:
摘要: Healthy immune function depends on precise regulation of lymphocyte activation. During the National Aeronautics and Space Administration (NASA) Apollo Shuttle eras, multiple spaceflight studies showed depressed activity under microgravity (μg) conditions. Scientists ground use two models simulated μg (sμg): 1) rotating wall vessel (RWV) 2) random positioning machine (RPM), to study effects altered gravity cell before advancing research true when opportunities become available International Station (ISS). The objective this is compare sμg expression key early T-cell activation genes in mouse splenocytes from animals. For first time, we compared all three conditions spaceflight, RPM, RWV during gene Il2, Il2rα, Ifnγ, Tagap; moreover, confirm new genes, Iigp1 Slamf1...
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