Determination of the Molecular Mechanisms Responsible for Abnormal CD43 Expression in Breast Cancer

摘要: Abstract : Human CD43 is a large, abundant and highly charged transmembrane molecule which inhibits intercellular interaction. Normally expression restricted to the surface of hematopoietic cells. However, primary breast cancer tumors their metastases also exhibit expression. Despite linkage between abnormal expression, molecular mechanisms responsible for this have never been investigated. The goal project elucidate these mechanisms. In first year we shown that cell line MCF-7 exhibits addition, demonstrated in vitro proximal promoter region directs normal gene mediated by transcription factors Puroc hnRNP-K. Our results demonstrate tissue culture lines can be used test novel strategies treatment based on targeting CD43. We determined such could now include specific manipulation Pura hnRNP-K