Bioactive compounds from marine Streptomyces sp. VITPSA as therapeutics

摘要: Marine actinomycetes are efficient producers of new secondary metabolites that show different biological activities, including antibacterial, antifungal, anticancer, insecticidal, and enzyme inhibition activities. The morphological, physiological, biochemical properties the strain Streptomyces sp. VITPSA were confirmed by conventional methods. Antibacterial, anti-oxidant, anti-inflammatory, anti-diabetic, cytotoxic activities extract determined. media optimized for production metabolites. Characterization identification conducted high-performance liquid chromatography, gas chromatography-mass spectroscopy, Fourier transform infrared spectroscopy analysis. showed significant moderate anti-inflammatory activity, no satisfactory anti-diabetic activity. ethyl acetate maximum antibacterial activity against two gram-positive gram-negative bacteria at 0.5 mg/mL. antioxidant potential crude exhibited strong reducing power mg/mL with 95.1% inhibition. effect was found to be an IC50 50 μg/mL on MCF-7 cell lines. Experimental design optimization one-factor analysis revealed most favorable sucrose, yeast extract, pH (7.25), temperature (28°C) conditions effective This study is excellent source various bioactivities.